Nicorette Original 4mg 210’s gum UK In Pakistan

Nicorette Original 4mg 210’s gum is available in Pakistan and can be purchased from various online retailers such as Vitamin Collection.

• Each piece contains 4mg of nicotine to help relieve withdrawal symptoms and cravings for those who smoke more than 20 cigarettes per day
• Comes in a pack of 210 pieces
• Product of UK
• Helps gradually reduce nicotine intake while adjusting to a smoke-free lifestyle

To use Nicorette gum effectively, chew a piece whenever you feel an urge to smoke, but no more than 15 pieces per day. Chew the gum until the taste becomes strong, then rest it between your gum and cheek until the taste fades. Repeat this process for up to 30 minutes.Nicorette gum is a medicine, so it’s important to follow the proper chewing technique to avoid releasing the nicotine too quickly and experiencing potential side effects like an irritated throat, upset stomach, or hiccups.

• Nicorette gum can be used during pregnancy, but it’s best to speak to your doctor or pharmacist first before taking any nicotine replacement therapy .
• Smoking during pregnancy can seriously harm your baby, so using Nicorette gum is considered a safer alternative than continuing to smoke .
• Fast-acting nicotine replacement products like gum may be preferable over slow-release patches when pregnant, as they can help satisfy cravings more quickly .
• It’s recommended to use Nicorette gum intermittently and try to reduce your nicotine intake as much as possible during pregnancy .
• Nicorette 4mg gum is suitable for heavier smokers who smoke more than 20 cigarettes per day .

Based on the search results, the key points regarding the effects of nicotine from gum on the fetus are:Nicotine Exposure and Fetal Health

• Nicotine from gum can readily cross the placenta and reach the fetus, with fetal concentrations generally 15% higher than maternal levels .
• Nicotine exposure during pregnancy is associated with increased risks of spontaneous abortion, premature delivery, and decreased birth weight .
• Animal studies have shown that fetal and neonatal nicotine exposure can lead to long-term adverse effects on the offspring, including impaired fertility, metabolic disorders, cardiovascular problems, and neurobehavioral deficits .

Risks of Nicotine Replacement Therapy (NRT) During Pregnancy

• While NRT like nicotine gum is considered safer than continued smoking, the long-term effects on the developing fetus are not fully known .
• Healthcare providers recommend trying to quit smoking without NRT first, as the risks to the child from nicotine gum are not fully understood .
• If using NRT during pregnancy, it should only be done under the guidance and supervision of a healthcare provider .

Key Benefits

• Helps control nicotine cravings and withdrawal symptoms associated with quitting smoking
• Slowly releases nicotine to combat cravings and reduce anxiety, frustration, irritability, and restlessness
• Provides a pleasant chewing experience as part of nicotine replacement therapy
• Suitable for heavier smokers who smoke more than 20 cigarettes per day

Key Ingredients

• Nicotine polacrilex (equal to 4mg nicotine) – the active ingredient that acts as a stop-smoking aid
• D&C yellow #10 – a coloring agent
• Flavors
• Glycerin
• Gum base
• Sodium carbonate
• Sorbitol

The key mechanism of action of Nicorette Original 4mg nicotine gum is:Nicotine Receptor Binding and Dopamine Release

• Nicotine in the gum binds to nicotinic acetylcholine receptors (nAChRs) in the brain, particularly in the ventral tegmental area .
• This binding stimulates the release of dopamine in the nucleus accumbens, the brain’s reward center .
• The release of dopamine produces pleasurable feelings and reduces the symptoms of nicotine withdrawal, helping to curb cravings for cigarettes .

Biphasic Nicotine Delivery

• The Nicorette gum is formulated to provide a biphasic nicotine delivery profile :
  1. An initial rapid release of nicotine to quickly relieve cravings and withdrawal symptoms
  2. A more gradual, sustained release of nicotine to maintain blood levels and prevent breakthrough cravings

Buccal Absorption

• The nicotine in the gum is absorbed through the buccal (cheek) mucosa when the gum is chewed and held in the mouth .
• This buccal absorption allows the nicotine to enter the bloodstream directly, bypassing first-pass metabolism in the liver.